Protein Domain : IPR011145

Type:  Domain Name:  Scavenger mRNA decapping enzyme, N-terminal
Description:  This entry represents the N-terminal domain of scavenger mRNA decapping enzymes, such as Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrate to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP) []. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues []. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. This family is related to Short Name:  Scavenger_mRNA_decap_enz_N
Paste the following link

0 Child Features

0 Contains

1 Cross References

Identifier
SSF102860

1 Found In

DB identifier Type Name
IPR008594 Family Scavenger mRNA decapping enzyme DcpS/DCS2

2 GO Annotations

GO Term Gene Name
GO:0016787 IPR011145
GO:0000290 IPR011145

2 Ontology Annotations

GO Term Gene Name
GO:0016787 IPR011145
GO:0000290 IPR011145

0 Parent Features

12 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
18391 I0YQ43 PAC:27395058 Coccomyxa subellipsoidea C-169 284  
152650 C1MPA0 PAC:27347310 Micromonas pusilla CCMP1545 336  
99594 C1E275 PAC:27397999 Micromonas sp RCC299 341  
Cre10.g432650.t1.1 A0A2K3D9Y9 PAC:30790796 Chlamydomonas reinhardtii 327  
SapurV1A.0107s0250.1.p PAC:31445726 Salix purpurea 544  
Cz14g18040.t1 PAC:38243548 Chromochloris zofingiensis 71  
Bobra.0022s0062.1.p PAC:40723251 Botryococcus braunii 316  
Cocit.L4519.1.p PAC:41062896 Corymbia citriodora 253  
SpFC.03G052400.1.p PAC:41738137 Salix purpurea Fish Creek 544  
Sapur.003G051300.1.p PAC:41792832 Salix purpurea 544  
Sapur.003G051300.2.p PAC:41792833 Salix purpurea 531  
Vocar.0019s0116.1.p PAC:32892611 Volvox carteri 308  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16246173
            16001405