| Type: | Domain | Name: | Allophanate hydrolase subunit 1 |
| Description: | Allophanate hydrolase catalyses the second reaction in an ATP-dependent, two-step degradation of urea to ammonia and C02. This follows the action of the biotin-containing urea carboxylase. Saccharomyces cerevisiaecan use urea as a sole nitrogen source via this degradation pathway []. In yeast, the fusion of allophanate hydrolase to urea carboxylase is called urea amidolyase.In bacteria, the second step in the urea degradation pathway is also the ATP-dependent allophanate hydrolase. The gene encoding this enzyme is found adjacent to the urea carboxylase gene []. Allophanate hydrolase has strict substrate specificity, as analogues of allophanate are not hydrolysed by it [].This domain represents subunit 1 of allophanate hydrolase (AHS1), which is found in urea carboxylase and the homologous Kinase A inhibitor KipI. | Short Name: | Allophan_hydro_1 |
