Protein Domain : IPR001759

Type:  Family Name:  Pentaxin-related
Description:  This entry represents Pentaxins and its related proteins such as CRP (C-reactive protein) and SAP (serum amyloid P component protein). This entry also includes adhesion G-protein coupled receptor D2 from humans. Pentaxins (or pentraxins) [, ] are a family of proteins which show, under electron microscopy, a discoid arrangement of five noncovalently bound subunits. Proteins of the pentaxin family are involved in acute immunological responses []. Three of the principal members of the pentaxin family are serum proteins: namely, C-reactive protein (CRP) [], serum amyloid P component protein (SAP) [], and female protein (FP) [].CRP is expressed during acute phase response to tissue injury or inflammation in mammals. The protein resembles antibody and performs several functions associated with host defence: it promotes agglutination, bacterial capsular swelling and phagocytosis, and activates the classical complement pathway through its calcium-dependent binding to phosphocholine. CRPs have also been sequenced in an invertebrate, Limulus polyphemus(Atlantic horseshoe crab), where they are a normal constituent of the hemolymph.SAP is a vertebrate protein that is a precursor of amyloid component P. It is found in all types of amyloid deposits, in glomerular basement menbrane and in elastic fibres in blood vessels. SAP binds to various lipoprotein ligands in a calcium-dependent manner, and it has been suggested that, in mammals, this may have important implications in atherosclerosis and amyloidosis.FP is a SAP homologue found in Mesocricetus auratus(Golden hamster). The concentration of this plasma protein is altered by sex steroids and stimuli that elicit an acute phase response.Pentaxin proteins expressed in the nervous system are neural pentaxin I (NPI) and II (NPII) []. NPI and NPII are homologous and can exist within one species. It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in synaptic plasticity. Apexin, a sperm acrosomal protein, is a homologue of NPII found in Cavia porcellus(Guinea pig) [].PTX3 (or TSG-14) protein is a cytokine-induced protein that is homologous to CRPs and SAPs, but its function is not yet known. Short Name:  Pentaxin-related
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PR00895
SM00159

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
45084 I0YKN2 PAC:27395168 Coccomyxa subellipsoidea C-169 927  
Cre07.g325744.t1.1 A0A2K3DJG4 PAC:30775150 Chlamydomonas reinhardtii 1315  
Dusal.0397s00015.1.p PAC:33200225 Dunaliella salina 438  
Cz01g14220.t1 PAC:38236434 Chromochloris zofingiensis 1049  
Bobra.53_2s0017.2.p PAC:40722069 Botryococcus braunii 507  
Bobra.53_2s0017.1.p PAC:40722068 Botryococcus braunii 984  
Bobra.0187s0105.1.p PAC:40719405 Botryococcus braunii 366  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            6356809
            9514915
            9614930
            7772283
            8884281
            7798266
            9583999