Protein Domain : IPR006581

Type:  Domain Name:  VPS10
Description:  Yeast Vps10p is a receptor for sorting and transport of the soluble vacuolar hydrolase carboxypeptidase Y to the lysosome-like vacuole []. In mammalian cells, proteins containing this domain are involved in the transport of lipoproteins and sorting of endosomal proteins. They may also act as receptors for some neuropeptides.The N terminus of murine brain SorCS contains two putative cleavage sites for the convertase furin which mark the beginning of the VPS10domain, which is followed by a module of imperfect leucine-rich repeats and a transmembrane domain. Theshort intracellular C terminus contains consensus signals for rapidinternalization. The identified putative binding motifs for SH2 and SH3 domains are unique in the family ofVPS10 domain receptors. SorCS is predominantly expressed in brain, but also in heart,liver, and kidney. SorCS transcripts detected by in situ hybridization in the murine centralnervous system point to a neuronal expression [, ]. Short Name:  VPS10
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR002860 Repeat BNR repeat

1 Cross References

Identifier
SM00602

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016021 IPR006581

1 Ontology Annotations

GO Term Gene Name
GO:0016021 IPR006581

0 Parent Features

8 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
46791 I0Z176 PAC:27387415 Coccomyxa subellipsoidea C-169 918  
209938 C1MQR7 PAC:27346097 Micromonas pusilla CCMP1545 867  
105132 C1DY99 PAC:27396485 Micromonas sp RCC299 845  
32702 A4S0D4 PAC:27414116 Ostreococcus lucimarinus 753  
Cre16.g662250.t1.1 A0A2K3CTL8 PAC:30777116 Chlamydomonas reinhardtii 877  
Cz04g09020.t1 PAC:38235036 Chromochloris zofingiensis 811  
Bobra.0327s0006.1.p PAC:40712534 Botryococcus braunii 905  
Vocar.0041s0024.1.p PAC:32888754 Volvox carteri 928  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11801606
            10600506
            10329739