Protein Domain : IPR007882

Type:  Family Name:  Microtubule-associated protein 6
Description:  Microtubule-associated protein 6 (MAP6) is a calmodulin binding protein that is involved in microtubule stabilisation []. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. MAP6 is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity []. MAP6 interacts with TMEM106B, and this interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport []. TMEM106B is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology. Short Name:  MAP6
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR14759

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005516 IPR007882
GO:0008017 IPR007882
GO:0000226 IPR007882
GO:0005874 IPR007882

4 Ontology Annotations

GO Term Gene Name
GO:0005516 IPR007882
GO:0008017 IPR007882
GO:0000226 IPR007882
GO:0005874 IPR007882

1 Parent Features

DB identifier Type Name
IPR024963 Family MAP6/FAM154

8 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Solyc08g005940.1.1 PAC:36150364 Solanum lycopersicum 459  
AUR62036182-RA PAC:36307691 Chenopodium quinoa 353  
AUR62036183-RA PAC:36307646 Chenopodium quinoa 412  
AUR62009760-RA PAC:36321788 Chenopodium quinoa 451  
AUR62009761-RA PAC:36321593 Chenopodium quinoa 350  
AH022413-RA PAC:38163873 Amaranthus hypochondriacus 346  
Solyc08g005940.1.1 PAC:41487282 Solanum lycopersicum 459  
EL10Ac7g15822.1 PAC:43406233 Beta vulgaris 435  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12231625
            16806091
            24357581