1 Proteins
DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
---|---|---|---|---|
Solyc12g062960.1.1 | PAC:36148031 | Solanum lycopersicum | 618 |
Type: | Family | Name: | Polycystic kidney disease type 1 protein |
Description: | Polycystin-1 (PC1) plays a critical role in renal tubule diameter control. Mutations in the polycystin-1 gene cause cyst formation in human autosomal dominant polycystic kidney disease [, ]. It may serve as a cell surface signaling receptor at cell-cell/cell-matrix junctions and as a mechano-sensor in renal primary cilia that activates signalling pathways involved in renal tubular differentiation [].Polycystin-1 contains an REJ (receptor for egg jelly) domain and a GPS (G protein-coupled receptor proteolytic site) domain in its N-terminal extracellular region (ectodomain). It can be cleaved into N-terminal fragment (NTF) and C-terminal fragment (CTF) at the GPS domain []. The GPS cleavage may play an important role for the biological function of PC1 []. | Short Name: | PC1 |
DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
---|---|---|---|---|
Solyc12g062960.1.1 | PAC:36148031 | Solanum lycopersicum | 618 |