Protein Domain : IPR009148

Type:  Family Name:  Streptococcal non-M secreted SibA
Description:  At present, Streptococci are amongst the most medically important bacterial species, causing a variety of diseases across a wide range of age groups.They are non-motile, Gram-positive cocci that are facultative or obligate anaerobes, and occur in pairs or chains. These microbes can be separatedinto groups according to their serological specificity, group A Streptococci (GAS) being amongst the most virulent and showing the most antibioticresistance. To combat the sudden surge of infections caused by GAS, namely Streptococcus pyogenesand Streptococcus pneumoniae, researchers have turned to the wealth of information contained within streptococcal genomes as a source of novel drug and vaccine targets. This, coupled with other techniques, such as microarray analysis and comparative genomics, are providing insights into the variations between clinical strains and avirulent commensal bacteria. Virulence factors, like the well-characterised glucan-binding protein from Streptococcus mutansare useful in assigning function to novel ORFs in new genomes.An example of this approach is the recent discovery of the SibA secreted protein of S. pyogenes, an immunoglobulin binding moiety that is completelydifferent from the classical Ig-binding M protein of other GAS isolates [].It shows similarity to other GAS glucan-binding proteins and secreted antigens, suggesting a common ancestor. Deletional studies in vitro showed that it is essential for virulence, and has several homologues in other Gram-positive pathogens. Short Name:  SibA

0 Child Features

1 Contains

DB identifier Type Name
IPR007921 Domain CHAP domain

1 Cross References

Identifier
PR01852

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

16 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
198921 PAC:27340256 Micromonas pusilla CCMP1545 454  
Cre12.g527500.t1.2 A0A2K3D4J8 PAC:30791797 Chlamydomonas reinhardtii 649  
Cre05.g246400.t1.2 A0A2K3DS46 PAC:30783263 Chlamydomonas reinhardtii 380  
Cre07.g319800.t1.2 A0A2K3DIZ3 PAC:30775173 Chlamydomonas reinhardtii 543  
Cre08.g384200.t1.2 A0A2K3DIA5 PAC:30773657 Chlamydomonas reinhardtii 1000  
Cre09.g397150.t1.1 A0A2K3DD29 PAC:30780489 Chlamydomonas reinhardtii 852  
Pavir.2KG190600.1.p PAC:37565298 Panicum virgatum 355  
Pavir.2KG296700.1.p PAC:37566715 Panicum virgatum 228  
Pum0389s0006.1.p A0A1X6NX60 PAC:38009273 Porphyra umbilicalis 506  
Pum0333s0017.1.p A0A1X6NYC2 PAC:38014834 Porphyra umbilicalis 319  
Pum1930s0001.2.p A0A1X6NKA9 PAC:38009054 Porphyra umbilicalis 497  
Pum1930s0001.1.p A0A1X6NKA9 PAC:38009053 Porphyra umbilicalis 497  
Pum1870s0001.1.p A0A1X6NKK0 PAC:38011320 Porphyra umbilicalis 439  
Pum0877s0001.1.p A0A1X6NNJ3 PAC:38018103 Porphyra umbilicalis 517  
Pum0306s0022.1.p A0A1X6NZW3 PAC:38014158 Porphyra umbilicalis 482  
Vocar.0021s0042.1.p PAC:32895911 Volvox carteri 1447  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11447160