Protein Domain : IPR027139

Type:  Family Name:  TNF receptor-associated factor 6
Description:  TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ]. Short Name:  TRAF6
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10131:SF52

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004842 IPR027139
GO:0006955 IPR027139
GO:0007165 IPR027139
GO:0016567 IPR027139

4 Ontology Annotations

GO Term Gene Name
GO:0004842 IPR027139
GO:0006955 IPR027139
GO:0007165 IPR027139
GO:0016567 IPR027139

1 Parent Features

DB identifier Type Name
IPR012227 Family TNF receptor-associated factor TRAF

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
182558 PAC:27344651 Micromonas pusilla CCMP1545 858  
93482 A4S540 PAC:27420628 Ostreococcus lucimarinus 726  
Cre14.g630150.t1.1 A0A2K3CYN7 PAC:30776483 Chlamydomonas reinhardtii 2510  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10215628
            14579250
            17633022
            15125833
            17135271
            14499111