Protein Domain : IPR003421

Type:  Domain Name:  Opine dehydrogenase
Description:  This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. This domain is found primarily in octopine dehydrogenase (), nopaline dehydrogenase (), and lysopine dehydrogenase (). NADPH is the preferred cofactor, but NADH is also used. Octopine dehydrogenase is involved in the reductive condensation of arginine and pyruvic acid to D-octopine [].Opine dehydrogenases can be found in both bacteria and marine cephalopods. In bacteria, some of these opine dehydrogenases are involved in crown gall tumours that are produced by Agrobacterium spp., and which encode for the opine dehydrogenases on a Ti-plasmid. These bacteria can transfer a portion of this plasmid (T-DNA) to a susceptible plant cell; the T-DNA then integrates into the plant nuclear genome, where its genes can be expressed. Some of these genes direct the synthesis and secretion of unusual amino acid and sugar derivatives called opines - these opines are used as a carbon and sometimes a nitrogen source by the infecting bacteria.Opine dehydrogenases are also found in the marine invertebrate cephalopods (octopuses, squid, and cuttlefish). For example in marine cephalopods, octopine dehydrogenase activity in mantle muscle is significantly correlated with a species' ability to buffer the acidic end products of anaerobic metabolism, with activity declining strongly with a species' habitat depth []. Short Name:  Opine_DH
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02317

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR003421
GO:0050662 IPR003421
GO:0055114 IPR003421

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR003421
GO:0050662 IPR003421
GO:0055114 IPR003421

1 Parent Features

DB identifier Type Name
IPR013328 Domain 6-phosphogluconate dehydrogenase, domain 2

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
57138 C1MQ29 PAC:27346188 Micromonas pusilla CCMP1545 533  
60684 C1FFZ7 PAC:27403271 Micromonas sp RCC299 506  
Cre09.g392652.t1.1 A0A2K3DDE2 PAC:30780864 Chlamydomonas reinhardtii 852  
Brdisv1pangenome1010014m.p PAC:33622880 Brachypodium distachyon Pangenome 386  
Brdisv1pangenome1011526m.p PAC:33655647 Brachypodium distachyon Pangenome 697  
Brdisv1BdTR11A1047778m.p PAC:35687678 Brachypodium distachyon BdTR11a 386  
Brdisv1BdTR11A1040051m.p PAC:35689443 Brachypodium distachyon BdTR11a 672  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9665174
            10786948