Protein Domain : IPR003709

Type:  Domain Name:  Peptidase M15B
Description:  These proteins are metallopeptidases belonging to MEROPS peptidase family M15 (clan MD), subfamily M15B (vanY D-Ala-D-Ala carboxypeptidase). Acquired VanA- and VanB-type glycopeptide resistance in enterococci is due to synthesis of modified peptidoglycan precursors terminating in D-lactate. As opposed to VanA-type strains which are resistant to both vancomycin and teicoplanin, VanB-type strains remain teicoplanin susceptible []. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides []. Short Name:  Pept_M15B
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02557

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008233 IPR003709
GO:0006508 IPR003709

2 Ontology Annotations

GO Term Gene Name
GO:0008233 IPR003709
GO:0006508 IPR003709

1 Parent Features

DB identifier Type Name
IPR009045 Domain Hedgehog signalling/DD-peptidase zinc-binding domain

27 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
18607 C1MVR7 PAC:27341085 Micromonas pusilla CCMP1545 182  
Sphfalx0007s0036.1.p PAC:32625523 Sphagnum fallax 355  
Pp3c5_5140V3.2.p A9S1S9 PAC:32952882 Physcomitrium patens 387  
Pp3c5_5140V3.1.p A9S1S9 PAC:32952881 Physcomitrium patens 387  
Sphmag05G105800.9.p PAC:41910719 Sphagnum magellanicum 313  
Sphmag05G105800.6.p PAC:41910728 Sphagnum magellanicum 250  
Sphmag05G105800.5.p PAC:41910718 Sphagnum magellanicum 320  
Sphmag05G105800.4.p PAC:41910716 Sphagnum magellanicum 338  
Sphmag05G105800.19.p PAC:41910717 Sphagnum magellanicum 338  
Sphmag05G105800.18.p PAC:41910715 Sphagnum magellanicum 366  
Sphmag05G105800.1.p PAC:41910714 Sphagnum magellanicum 366  
Sphmag05G105800.21.p PAC:41910734 Sphagnum magellanicum 197  
Sphmag05G105800.20.p PAC:41910733 Sphagnum magellanicum 197  
Sphmag05G105800.10.p PAC:41910731 Sphagnum magellanicum 222  
Sphmag05G105800.13.p PAC:41910732 Sphagnum magellanicum 204  
Sphfalx05G101500.11.p PAC:41962468 Sphagnum fallax 309  
Sphfalx05G101500.3.p PAC:41962467 Sphagnum fallax 334  
Sphfalx05G101500.6.p PAC:41962469 Sphagnum fallax 298  
Sphfalx05G101500.1.p PAC:41962466 Sphagnum fallax 364  
Sphfalx05G101500.9.p PAC:41962474 Sphagnum fallax 250  
Sphfalx05G101500.4.p PAC:41962473 Sphagnum fallax 250  
Sphfalx05G101500.12.p PAC:41962470 Sphagnum fallax 279  
Sphfalx05G101500.8.p PAC:41962472 Sphagnum fallax 250  
Sphfalx05G101500.2.p PAC:41962477 Sphagnum fallax 220  
CepurR40.7G098900.1.p PAC:43026296 Ceratodon purpureus R40 375  
CepurR40.1G087400.1.p PAC:43006833 Ceratodon purpureus R40 125  
CepurGG1.7G092400.1.p PAC:43047307 Ceratodon purpureus GG1 375  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8631706
            1398115