Protein Domain : IPR001259

Type:  Repeat Name:  Proteinase inhibitor I27, calpastatin
Description:  This entry represents repeats on calpain inhibitor proteins. Calpain inhibitor (calpastatin) is restricted to the metazoa and specifically inhibits calpain (calcium-dependent cysteine protease) []. Calpastatin belongs to MEROPS inhibitor family I27, clan II. It plays a key role in post-mortem tenderisation of meat and may be involved in muscle protein degradation in living tissue.The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only known function is to inhibit the two calpains. Both mu- and m-calpain are heterodimers containing an identical 28kDa subunit and an 80kDa subunit that shares 55-65% sequence homology between the two proteases. The single calpastatin gene can produce eight or more calpastatin polypeptides ranging from 17kDa to 85kDa by use of different promoters and alternative splicing events. The physiological significance of these different calpastatins is unclear, although all bind to three different places on the calpain molecule; binding to at least two of the sites is Ca2+ dependent. How calpain activity is regulated in cells is still unclear, but the calpains ostensibly participate in a variety of cellular processes including remodelling of cytoskeletal/membrane attachments, different signal transduction pathways, and apoptosis. Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma []. Short Name:  Prot_inh_calpain
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0 Child Features

0 Contains

1 Cross References

Identifier
PF00748

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
AUR62003121-RA PAC:36301558 Chenopodium quinoa 250  
Eusyr.0134s0458.1.p PAC:39710191 Euclidium syriacum 267  
Spov3_chr1.02989 PAC:45120387 Spinacia oleracea 347  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12843408
            15255177