| Type: | Family | Name: | Cavin family |
| Description: | This entry represents cavin family (previously known as the PTRF/SDPR family), which includes proteins newly named as cavin-1 to 4. They are critical regulators for caveolae dynamics []. Caveolae are invaginations of the plasma membrane involved in many cellular processes, including clathrin-independent endocytosis, cholesterol transport, and signal transduction. Caveolins are the principal components of caveolae membranes. Polymerase I and transcript release factor (PTRF; also known as cavin-1) is essential for formation of caveolae and proper localisation of caveolins []. Cavin-2 (also known as serum deprivation-response protein) may play a role in targeting protein kinase C alpha (PKCalpha) to caveolae []. Cavin-3 (protein kinase C delta-binding protein, also known as SRBC) seems to have an immune potentiation function, especially in the glioma [, ]. Cavin-4 (muscle-related coiled-coil protein) is a muscle-restricted cavin[].The members of the cavin family contain putative leucine zipper-like domains normally involved in protein-protein interactions and PEST domains (proline, glutamic acid, serine and threonine-rich domains), which may play a role in targeting proteins towards proteolytic degradation []. | Short Name: | Cavin_fam |
