Protein Domain : IPR000879

Type:  Family Name:  Guanylin
Description:  This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases. Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [, ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea []. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins []. Short Name:  Guanylin
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0 Child Features

0 Contains

7 Cross Referencess

Identifier
PTHR11318
PF02058
PIRSF001849
PR00774
PD005588
G3DSA:3.90.1450.10
SSF89890

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0030250 IPR000879
GO:0005576 IPR000879

2 Ontology Annotations

GO Term Gene Name
GO:0030250 IPR000879
GO:0005576 IPR000879

0 Parent Features

160 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94241 A4RX00 PAC:27416461 Ostreococcus lucimarinus 380  
Cre03.g203351.t1.2 A0A2K3DZ80 PAC:30787900 Chlamydomonas reinhardtii 1655  
Spipo26G0009700 PAC:31515142 Spirodela polyrhiza 120  
Manes.11G091000.1.p A0A2C9V1A5 PAC:32355143 Manihot esculenta 95  
Pahal.J01232.2 A0A270R6E3 PAC:32517439 Panicum hallii 652  
Pahal.J01232.1 A0A270R6T6 PAC:32517438 Panicum hallii 653  
Kalax.0001s0113.4.p PAC:32559809 Kalanchoe laxiflora 544  
Kalax.0001s0113.3.p PAC:32559810 Kalanchoe laxiflora 539  
Kalax.0001s0113.2.p PAC:32559811 Kalanchoe laxiflora 538  
Kalax.0001s0113.9.p PAC:32559807 Kalanchoe laxiflora 548  
Kalax.0001s0113.10.p PAC:32559813 Kalanchoe laxiflora 522  
Kalax.0001s0113.18.p PAC:32559818 Kalanchoe laxiflora 486  
Kalax.0001s0113.13.p PAC:32559824 Kalanchoe laxiflora 463  
Kalax.0001s0113.16.p PAC:32559822 Kalanchoe laxiflora 485  
Kalax.0001s0113.12.p PAC:32559823 Kalanchoe laxiflora 463  
Kalax.0001s0113.15.p PAC:32559821 Kalanchoe laxiflora 485  
Kalax.0001s0113.8.p PAC:32559812 Kalanchoe laxiflora 526  
Kalax.0001s0113.17.p PAC:32559817 Kalanchoe laxiflora 486  
Kalax.0001s0113.7.p PAC:32559815 Kalanchoe laxiflora 516  
Kalax.0001s0113.14.p PAC:32559820 Kalanchoe laxiflora 485  
Kalax.0001s0113.6.p PAC:32559816 Kalanchoe laxiflora 515  
Kalax.0001s0113.11.p PAC:32559814 Kalanchoe laxiflora 521  
Kalax.0001s0113.19.p PAC:32559819 Kalanchoe laxiflora 486  
Kalax.0455s0011.4.p PAC:32538949 Kalanchoe laxiflora 486  
Kalax.0455s0011.3.p PAC:32538948 Kalanchoe laxiflora 515  
Kalax.0455s0011.2.p PAC:32538947 Kalanchoe laxiflora 516  
Kalax.0455s0011.1.p PAC:32538946 Kalanchoe laxiflora 539  
Kalax.0455s0011.5.p PAC:32538950 Kalanchoe laxiflora 463  
Kalax.0524s0007.2.p PAC:32563308 Kalanchoe laxiflora 560  
Kalax.0524s0007.1.p PAC:32563307 Kalanchoe laxiflora 563  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7713512
            1409606
            1346555