1 Proteins
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Pavir.9NG427100.1.p | PAC:37656459 | Panicum virgatum |
702
 |
| Type: | Family | Name: | Ribonucleotide reductase, class 1b, subunit NrdE |
| Description: | Ribonucleotide reductase (also known as ribonucleoside-diphosphate reductase) catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides providing the precursors necessary for DNA synthesis. Three main classes of ribonucleotide reductases (RNR) have been discovered that depend on different metal cofactors for the catalytic activity: class I enzymes contain a diiron-oxygen cluster, class II a cobalt containingcobalamin cofactor (vitamin B12), and class III an 4Fe-4S iron-sulfur cluster coupled to S-adenosylmethionine (SAM) [].Class I RNRs can be further divided into two subclasses, Ia and Ib. Class Ia exists in eukaryotes, prokaryotes, viruses, and bacteriophages, while Ib has only been found in prokaryotes. Class I RNRs are tetrameric enzymes (alpha2beta2). The substrate binding active site is located in the large alpha2-homodimer which is called R1 in class Ia, encoded by nrdA, and R1E in class Ib, encoded by nrdE [].Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form of ribonucleotide reductase uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron []. | Short Name: | RNR_1b_NrdE |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Pavir.9NG427100.1.p | PAC:37656459 | Panicum virgatum |
702
|
