Protein Domain : IPR001292

Type:  Family Name:  Oestrogen receptor
Description:  Steroid or nuclear hormone receptors (4A nuclear receptor, NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands []. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The oestrogen receptors (ERs) are steroid or nuclear hormone receptors that act as transcription regulators involved in diverse physiological functions. Oestrogen receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. The ER consists of three functional and structural domains: an N-terminal modulatory domain, a highly conserved DNA-binding domain that recognises specific sequences (), and a C-terminal ligand-binding domain (). The N-terminal modulatory domain spans the first 180 residues and contains the activation function 1 (AF1) region. Nuclear receptors differ considerably with respect to AF1 activity and regulation, as it is a poorly conserved region []. There is another activation function region, namely AF2, which resides in the C-terminal end of the ligand-binding domain. Transcription activation is facilitated by both AF1 and AF2, which appear to act synergistically in the ER complex [, ]. For example, the ER can recruit TIF2 (transcription intermediary factor 2) via the AF1 and AF2 regions, whose synergistic action results in the activation of transcription. Short Name:  Oestr_rcpt
Paste the following link

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02159
PIRSF500101
PR00543

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0003677 IPR001292
GO:0005496 IPR001292
GO:0030284 IPR001292
GO:0006355 IPR001292
GO:0043401 IPR001292
GO:0005634 IPR001292

6 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001292
GO:0005496 IPR001292
GO:0030284 IPR001292
GO:0006355 IPR001292
GO:0043401 IPR001292
GO:0005634 IPR001292

1 Parent Features

DB identifier Type Name
IPR024178 Family Oestrogen receptor/oestrogen-related receptor

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sobic.010G163000.1.p C5Z484 PAC:37910844 Sorghum bicolor 529  
SbRio.10G213800.1.p PAC:38998618 Sorghum bicolor Rio 529  
SbiRTX430.10G173600.3.p C5Z484 PAC:43545390 Sorghum bicolor RTx430 529  
SbiBTX642.10G176200.1.p C5Z484 PAC:44422424 Sorghum bicolor BTx642 529  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7899080
            8165128
            14747695
            15728727
            14612550
            15831449