Protein Domain : IPR024972

Type:  Family Name:  HNS-dependent expression A
Description:  HNS (histone-like nucleoid structuring)-dependent expression A (HdeA) protein is a stress response protein found in highly acid resistant bacteria such as Shigella flexneriand Escherichia coli, but which is lacking in mildly acid tolerant bacteria such as Salmonella []. HdeA is one of the most abundant proteins found in the periplasmic space of E. coli, where it is one of a network of proteins that confer an acid resistance phenotype essential for the pathogenesis of enteric bacteria []. HdeA is thought to act as a chaperone, functioning to prevent the aggregation of periplasmic proteins denatured under acidic conditions. The HNS protein, a chromatin-associated protein that influences the gene expression of several environmentally-induced target genes, represses the expression of HdeA. HdeB, which is encoded within the same operon, may form heterodimers with HdeA. HdeA is a single domain alpha-helical [] protein with an overall fold that is similar to the fold of the N-terminal subdomain of the GluRS anticodon-binding domain. This entry represents acid stress chaperone HdeA. Short Name:  HdeA
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PIRSF009564
PD065392
SSF47752
MF_00946

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0071468 IPR024972
GO:0030288 IPR024972

2 Ontology Annotations

GO Term Gene Name
GO:0071468 IPR024972
GO:0030288 IPR024972

1 Parent Features

DB identifier Type Name
IPR010486 Family HNS-dependent expression A/B

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
AH008204-RA PAC:38180026 Amaranthus hypochondriacus 268  
Eruve.0511s0002.1.p PAC:39884353 Eruca vesicaria 260  
Crahi.0202s0014.1.p PAC:39972582 Crambe hispanica 249  
Spov3_chr1.04276 PAC:45125224 Spinacia oleracea 122  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12694615
            10623550