Protein Domain : IPR020091

Type:  Domain Name:  Pleiotrophin/Midkine disulphide-rich domain
Description:  Several extracellular heparin-binding proteins involved in regulation of growth and differentiation belong to a new family of growth factors. These growth factors are highly related proteins of about 140 amino acids that contain 10 conserved cysteines probably involved in disulphide bonds, and include pleiotrophin [] (also known as heparin-binding growth-associated molecule HB-GAM, heparin-binding growth factor 8 HBGF-8, heparin-binding neutrophic factor HBNF and osteoblast specific protein OSF-1); midkine (MK) []; retinoic acid-induced heparin-binding protein (RIHB) []; and pleiotrophic factors alpha-1and -2 and beta-1 and -2 from Xenopus laevis, the homologues of midkine and pleiotrophin respectively. Pleiotrophin is a heparin-binding protein that has neurotrophic activity and has mitogenic activity towards fibroblasts. It is highly expressed in brain and uterus tissues, but is also found in gut, muscle and skin. It is thought to possess an important brain-specific function. Midkine is a regulator of differentiation whose expression is regulated by retinoic acid, and, like pleiotrophin, is a heparin-binding growth/differentiation factor that acts on fibroblasts and nerve cells. Pleiotrophin is structurally divided into two domains, both domains consisting of three antiparallel beta-strands, but the C-terminal domain has a long flexible hairpin loop where a heparin-binding consensus sequence is located []. This entry represents the all-beta 3 antiparallel strands disulfide-rich fold found both in the N-terminal and C-terminal domains of pleiotrophin and midkine. Short Name:  PTN/MK_diS
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2 Child Features

DB identifier Type Name
IPR020089 Domain Pleiotrophin/Midkine, N-terminal domain
IPR020090 Domain Pleiotrophin/Midkine, C-terminal domain

1 Contains

DB identifier Type Name
IPR020092 Conserved_site Pleiotrophin/Midkine heparin-binding growth factor, conserved site

1 Cross References

Identifier
SSF57288

1 Found In

DB identifier Type Name
IPR000762 Family Midkine heparin-binding growth factor

1 GO Annotation

GO Term Gene Name
GO:0008083 IPR020091

1 Ontology Annotations

GO Term Gene Name
GO:0008083 IPR020091

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Thecc1EG021931t1 A0A061ES60 PAC:27422070 Theobroma cacao 127  
SapurV1A.0289s0120.1.p PAC:31405138 Salix purpurea 86  
Traes_3B_1CF39940A.1 PAC:31779987 Triticum aestivum 90  
Thecc.05G039100.1.p A0A061ES60 PAC:42030934 Theobroma cacao 127  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15047154
            7796887
            15121180
            9384573