| Type: | Family | Name: | Carbamate kinase |
| Description: | The arginine dihydrolase (AD) pathway is found in many prokaryotes and some primitive eukaryotes. The three- enzyme anaerobic pathway breaks down L-arginine to form 1 mol of ATP, carbon dioxide and ammonia. In simpler bacteria, the first enzyme, arginine deiminase, can account for up to 10% of total cell protein [].Carbamate kinase is involved in the last step of the AD pathway, converting carbamoyl phosphate and ADP into ammonia, carbon dioxide and ATP []. Thesecond step of the pathway involves the degradation of L-citrulline to carbamoyl phosphate and L-ornithine, using ornithine carbamoyltransferase [].The crystal structure of Enterococcus faeciumcarbamate kinase has been determined to 2.8A resolution []. The enzyme exists as ahomodimer of two 33kDa subunits. The hallmark of the dimer is a 16-stranded beta-sheet, surrounded by alpha-helices. Each subunit contains an activesite within a large crevice. | Short Name: | Carb_kinase |
