Protein Domain : IPR013013

Type:  Domain Name:  Phosphotransferase system, EIIC component, type 1
Description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [, ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars.The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred via a signal transduction pathway, to enzyme I (EI) which in turn transfers it to a phosphoryl carrier, the histidine protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease, a membrane-bound complex known as enzyme 2 (EII), which transports the sugar to the cell. EII consists of at least three structurally distinct domains IIA, IIB and IIC []. These can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The first domain (IIA or EIIA) carries the first permease-specific phosphorylation site, a histidine which is phosphorylated by phospho-HPr. The second domain (IIB or EIIB) is phosphorylated by phospho-IIA on a cysteinyl or histidyl residue, depending on the sugar transported. Finally, the phosphoryl group is transferred from the IIB domain to the sugar substrate concomitantly with the sugar uptake processed by the IIC domain. This third domain (IIC or EIIC) forms the translocation channel and the specific substrate-binding site. An additional transmembrane domain IID, homologous to IIC, can be found in some PTSs, e.g. for mannose [, , , ]. According to sequence analyses [, , ], the PTS EIIC domain can be divided in five groups:The PTS EIIC type 1 domain is found in the Glucose class of PTS and has an average length of about 80 amino acids. The PTS EIIC type 2 domain is found in the Mannitol class of PTS and has an average length of about 90 amino acids.The PTS EIIC type 3 domain is found in the Lactose class of PTS and has an average length of about 100 amino acids. The PTS EIIC type 4 domain is found in the Mannose class of PTS and has an average length of about 160 amino acids. The PTS EIIC type 5 domain is found in the Sorbitol class of PTS and has an average length of about 190 amino acids. This entry represents the type 1 domain. Short Name:  PTS_EIIC_1
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1 Child Features

DB identifier Type Name
IPR004719 Domain Phosphotransferase system, maltose/glucose-specific subfamily IIC component

0 Contains

1 Cross References

Identifier
PS51103

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR003352 Domain Phosphotransferase system, EIIC

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0077.1.p PAC:28856530 Arabidopsis halleri 478  
Brdisv1pangenome1005610m.p PAC:33624718 Brachypodium distachyon Pangenome 930  
Brdisv1pangenome1007360m.p PAC:33622517 Brachypodium distachyon Pangenome 924  
Brdisv1pangenome1008533m.p PAC:33622128 Brachypodium distachyon Pangenome 947  
Brdisv1BdTR11A1029459m.p PAC:35677832 Brachypodium distachyon BdTR11a 1082  
Brdisv1BdTR11A1044329m.p PAC:35696163 Brachypodium distachyon BdTR11a 1038  
Brdisv1BdTR11A1040147m.p PAC:35691612 Brachypodium distachyon BdTR11a 942  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2197982
            8246840
            1537788
            7815935
            11361063