| Type: | Domain | Name: | DNA-binding RFX-type winged-helix domain |
| Description: | The RFX family of transcription factors is characterised by a unique approximately 75-residue DNA-binding domain. RFX genes have been isolated in yeasts, nematode and vertebrates. The characteristic RFX-type HTH DNA binding domain has been recruited into otherwise very divergent regulatory factors functioning in a diverse spectrum of unrelated systems, including regulation of the mitotic cell cycle in fission yeast, the control of the immune response in mammals,and infection by human hepatitis B virus [, ]. The RFX-type DNA-binding domain is an unusual member of the winged-helix subfamily of helix-turn-helix domains because it uses a beta-hairpin (or wing)to recognise DNA instead of the recognition helix typical of helix-tun-helix domains. It consists of three alpha-helices (H), three beta-strands (S) andthree connecting loops (L), arranged in the order H1-S1-H2-L1-H3-L2-S2-W1-S3. The third loop, connecting beta-strands S2 and S3, forms wing W1 of thewinged-helix motif. In contrast to previously described winged-helix DBDs (typically 110 residues long with two wings, W1 and W2), theshorter RFX-type winged-helix DNA-binding domain has only one wing []. | Short Name: | DNA-bd_RFX |
| DB identifier | Type | Name |
|---|---|---|
| IPR011991 | Domain | Winged helix-turn-helix DNA-binding domain |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Cocit.L4185.1.p | PAC:41048820 | Corymbia citriodora |
838
 |
