Protein Domain : IPR011991

Type:  Domain Name:  Winged helix-turn-helix DNA-binding domain
Description:  Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif, where the "wings", or loops, are small beta-sheets. The winged helix motif consists of two wings (W1, W2), three alpha helices (H1, H2, H3) and three beta-sheets (S1, S2, S3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 []. The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA, while the wings make different DNA contacts, often with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain, including transcriptional repressors such as biotin repressor, LexA repressor and the arginine repressor []; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation, heat-shock transcription factor, and the general transcription factors TFIIE and TFIIF [, ]; helicases such as RuvB that promotes branch migration at the Holliday junction, and CDC6 in the pre-replication complex [, ]; endonucleases such as FokI and TnsA []; histones; and Mu transposase, where the flexible wing of the enhancer-binding domain is essential for efficient transposition []. Short Name:  WHTH_DNA-bd_dom
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38 Child Features

DB identifier Type Name
IPR015285 Domain RIO2 kinase winged helix domain, N-terminal
IPR000232 Domain Heat shock factor (HSF)-type, DNA-binding
IPR006630 Domain RNA-binding protein Lupus La
IPR005818 Domain Linker histone H1/H5, domain H15
IPR003316 Domain E2F/DP family, winged-helix DNA-binding domain
IPR015163 Domain Cdc6, C-terminal domain
IPR000591 Domain DEP domain
IPR000847 Domain Transcription regulator HTH, LysR
IPR016032 Domain Signal transduction response regulator, C-terminal effector
IPR001845 Domain HTH ArsR-type DNA-binding domain
IPR000524 Domain Transcription regulator HTH, GntR
IPR000485 Domain AsnC-type HTH domain
IPR002577 Domain Helix-turn-helix, HxlR type
IPR008823 Domain DNA helicase, Holliday junction RuvB type, C-terminal
IPR001766 Domain Fork head domain
IPR000835 Domain MarR-type HTH domain
IPR013196 Domain Helix-turn-helix, type 11
IPR005104 Domain Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain
IPR012318 Domain Crp-type HTH domain
IPR000607 Domain Double-stranded RNA-specific adenosine deaminase (DRADA)
IPR014048 Domain Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
IPR000418 Domain Ets domain
IPR005149 Domain Transcription regulator PadR, N-terminal
IPR006199 Domain LexA repressor, DNA-binding domain
IPR005561 Domain ANTAR domain
IPR004409 Domain Biotin operon repressor, helix-turn-helix domain
IPR003150 Domain DNA-binding RFX-type winged-helix domain
IPR015198 Domain Bacteriophage T4, MotA, transcription regulator N-terminal
IPR015191 Domain Translation elongation factor SelB, winged helix, type 3
IPR014793 Domain Dissimilatory sulphite reductase D

14 Contains

DB identifier Type Name
IPR017919 Domain Transcription factor TFE/TFIIEalpha HTH domain
IPR013324 Domain RNA polymerase sigma factor, region 3/4
IPR007630 Domain RNA polymerase sigma-70 region 4
IPR007624 Domain RNA polymerase sigma-70 region 3
IPR001867 Domain Signal transduction response regulator, C-terminal
IPR013196 Domain Helix-turn-helix, type 11
IPR016157 Conserved_site Cullin, conserved site
IPR001497 Active_site Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
IPR015189 Domain Translation elongation factor SelB, winged helix, type 1
IPR018335 Conserved_site Transcription regulator HTH, Crp-type, conserved site
IPR019885 Conserved_site Transcription regulator HTH, AsnC-type, conserved site
IPR019817 Conserved_site Interferon regulatory factor, conserved site
IPR018334 Conserved_site ArsR-type transcription regulator, HTH motif
IPR018122 Conserved_site Fork head domain conserved site1

1 Cross References

Identifier
G3DSA:1.10.10.10

66 Found Ins

DB identifier Type Name
IPR003196 Family Transcription initiation factor IIF, beta subunit
IPR002853 Family Transcription factor TFIIE, alpha subunit
IPR004085 Family DNA topoisomerase VI, subunit A
IPR009374 Family Eukaryotic translation initiation factor 3 subunit K
IPR002717 Domain Histone acetyltransferase domain, MYST-type
IPR014646 Family Replication factor A protein 2
IPR014892 Domain Replication protein A, C-terminal
IPR000717 Domain Proteasome component (PCI) domain
IPR016461 Family O-methyltransferase COMT-type
IPR012967 Domain Plant methyltransferase dimerisation
IPR005819 Family Histone H5
IPR014284 Domain RNA polymerase sigma-70 like domain
IPR000943 Domain RNA polymerase sigma-70
IPR016262 Family RNA polymerase sigma factor, SigB/C/D/F, plastid
IPR008851 Family Transcription initiation factor IIF, alpha subunit
IPR016656 Family Transcription initiation factor TFIIE, beta subunit
IPR001367 Domain Iron dependent repressor, metal binding and dimerisation domain
IPR019888 Family Transcription regulator AsnC-type
IPR005650 Family BlaI transcriptional regulatory family
IPR002571 Family Heat-inducible transcription repressor HrcA
IPR012759 Family RNA polymerase sigma factor RpoH, proteobacteria
IPR012760 Domain RNA polymerase sigma factor RpoD, C-terminal
IPR000525 Domain Initiator Rep protein
IPR016263 Family RNA polymerase sporulation-specific sigma factor
IPR017848 Family RNA polymerase sigma factor, RpoD-like, cyanobacteria
IPR005149 Domain Transcription regulator PadR, N-terminal
IPR004605 Family DNA helicase, Holliday junction RuvB type
IPR014209 Family RNA polymerase sigma-K type
IPR006291 Family Transcriptional regulatory protein PcoR, heavy metal response
IPR011879 Family Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB

0 GO Annotation

0 Ontology Annotations

0 Parent Features

98906 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134587 D8T8W9 PAC:15412114 Selaginella moellendorffii 280  
440877 D8RF34 PAC:15407972 Selaginella moellendorffii 649  
92634 D8RFD1 PAC:15419911 Selaginella moellendorffii 319  
231540 D8RHS0 PAC:15417541 Selaginella moellendorffii 482  
441100 D8RGG7 PAC:15405425 Selaginella moellendorffii 461  
93081 D8RHL1 PAC:15418385 Selaginella moellendorffii 178  
269977 D8TAX5 PAC:15420943 Selaginella moellendorffii 434  
430904 D8TAW8 PAC:15401459 Selaginella moellendorffii 107  
73118 D8RII1 PAC:15404470 Selaginella moellendorffii 59  
431747 D8TDN1 PAC:15402918 Selaginella moellendorffii 244  
236823 D8TE04 PAC:15412080 Selaginella moellendorffii 523  
172404 D8RLJ6 PAC:15411824 Selaginella moellendorffii 108  
441625 D8RLH3 PAC:15409372 Selaginella moellendorffii 399  
441628 D8RLI0 PAC:15409373 Selaginella moellendorffii 472  
441673 D8RLW2 PAC:15409475 Selaginella moellendorffii 332  
96219 D8RLZ5 PAC:15406128 Selaginella moellendorffii 322  
96266 D8RL60 PAC:15406260 Selaginella moellendorffii 489  
172620 D8RM97 PAC:15413424 Selaginella moellendorffii 766  
413041 D8RN56 PAC:15411439 Selaginella moellendorffii 242  
404596 D8QVU3 PAC:15411148 Selaginella moellendorffii 779  
404594 D8QVU1 PAC:15411147 Selaginella moellendorffii 433  
438299 D8QVV9 PAC:15419751 Selaginella moellendorffii 236  
79209 D8QVH1 PAC:15422774 Selaginella moellendorffii 724  
413266 D8RNW4 PAC:15413019 Selaginella moellendorffii 303  
441994 D8RPJ7 PAC:15411867 Selaginella moellendorffii 356  
98222 D8RP10 PAC:15412063 Selaginella moellendorffii 750  
98006 D8RP07 PAC:15410515 Selaginella moellendorffii 735  
173394 D8RQG0 PAC:15414234 Selaginella moellendorffii 752  
413826 D8RQC0 PAC:15417474 Selaginella moellendorffii 511  
413886 D8RQY3 PAC:15417638 Selaginella moellendorffii 377  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12408833
            9214510
            1409631
            10679470
            8248124
            11292844
            11030343
            8577730