Type: | Domain | Name: | Iron dependent repressor, metal binding and dimerisation domain |
Description: | The diphtheria toxin repressor protein (DTXR) is a member of this group []. In Corynebacterium diphtheriaewhere it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalentmetal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation []. | Short Name: | Fe_dep_repressor |