Protein Domain : IPR022689

Type:  Family Name:  Iron dependent repressor
Description:  This entry represents a group of iron dependent repressors, including MntR, IdeR and diphtheria toxin repressor. The diphtheria toxin repressor protein (DTXR) is a member of this group []. In Corynebacterium diphtheriaewhere it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalentmetal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation []. Short Name:  Iron_dep_repressor
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1 Child Features

DB identifier Type Name
IPR022897 Family Transcription regulator MntR

2 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR001367 Domain Iron dependent repressor, metal binding and dimerisation domain

1 Cross References

Identifier
SM00529

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003700 IPR022689
GO:0046914 IPR022689
GO:0006355 IPR022689

3 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR022689
GO:0046914 IPR022689
GO:0006355 IPR022689

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7568230
            7743135