Protein Domain : IPR015198

Type:  Domain Name:  Bacteriophage T4, MotA, transcription regulator N-terminal
Description:  Transcription factor MotA is required for the activation of middle promoters in Bacteriophage T4, in addition to phage T4 co-activator AsiA, and sigma-70-containing Escherichia coliRNA polymerase. Phage T4 middle promoters have the sigma70 -10 DNA element, but not the -35 element; instead, they have a MotA box at -30 to which the transcription factor MotA binds []. MotA and AsiA interact with the C-terminal of sigma70 (region 4), which normally binds the -35 element and the beta-flap, thereby diverting sigma70 away from host promoters that require -35 element-binding to phage T4 middle promoters. Transcription factor MotA has two domains: an N-terminal domain required for binding to sigma70, and a C-terminal domain required for binding to the -30 MotA box element in the phage T4 middle promoter. This entry represents the N-terminal (activation) domain of MotA factors that binds sigma70. The N-terminal domain adopts an almost completely alpha-helical topology, with five alpha-helices and a short, two-stranded, beta-ribbon. Four alpha helices (alpha1, alpha3, alpha4 and alpha5) are amphipathic and pack their hydrophobic surfaces around the central helix alpha2 []. Short Name:  Phage_T4_MotA_Tscrpt_reg_N
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0 Child Features

0 Contains

1 Cross References

Identifier
PF09114

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain

11 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
GlysoPI483463.19G044400.1.p PAC:41183197 Glycine soja 1073  
GlymaLee.19G045000.3.p PAC:41277782 Glycine max Lee 929  
GlymaLee.19G045100.2.p PAC:41278259 Glycine max Lee 1073  
GlymaLee.19G045100.1.p PAC:41278258 Glycine max Lee 1120  
GlymaLee.19G045100.3.p PAC:41278260 Glycine max Lee 1073  
GlymaLee.19G045100.4.p PAC:41278262 Glycine max Lee 704  
GlymaLee.19G045100.5.p PAC:41278261 Glycine max Lee 918  
GlymaLee.19G045000.2.p PAC:41277781 Glycine max Lee 992  
GlymaFiskIII.19G049700.5.p PAC:50790293 Glycine max Fiskeby 992  
GlymaFiskIII.19G049700.2.p PAC:50790295 Glycine max Fiskeby 554  
GlymaFiskIII.19G049700.4.p PAC:50790294 Glycine max Fiskeby 639  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9155025
            16996538