3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003700 | IPR018122 |
| GO:0043565 | IPR018122 |
| GO:0006355 | IPR018122 |
| Type: | Conserved_site | Name: | Fork head domain conserved site1 |
| Description: | This entry represents a conserved site found in the fork head domain, a conserved domain of about 100 amino-acid residues found in some eukaryotic transcription factors. The fork head domain is involved in DNA-binding []. The signature in this entry corresponds to the N-terminal section of the fork head domain. The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors []. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiaeHCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [, , ].The fork head domain binds B-DNA as a monomer [], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis []. | Short Name: | TF_fork_head_CS_1 |
| GO Term | Gene Name |
|---|---|
| GO:0003700 | IPR018122 |
| GO:0043565 | IPR018122 |
| GO:0006355 | IPR018122 |
