Protein Domain : IPR000418

Type:  Domain Name:  Ets domain
Description:  Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of genetranscription []. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [, , ]. This domain is rich inpositively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain has been identified in other transcription factorssuch as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [, , ].It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found atthe N terminus.NMR-analysis of the structure of the Ets domains revealed that it contains three alpha-helixes (1-3) and four-stranded beta-sheets (1-4) arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4 forming awinged helix-turn-helix (wHTH) topology []. The third alpha-helix isresponsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequencesof the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities. Short Name:  Ets_dom
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0 Child Features

0 Contains

6 Cross Referencess

Identifier
PF00178
PR00454
PS00345
PS00346
PS50061
SM00413

2 Found Ins

DB identifier Type Name
IPR016311 Family Transforming protein C-ets
IPR016312 Family Transcription factor, GA-binding, alpha subunit

3 GO Annotations

GO Term Gene Name
GO:0003700 IPR000418
GO:0043565 IPR000418
GO:0006355 IPR000418

3 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR000418
GO:0043565 IPR000418
GO:0006355 IPR000418

1 Parent Features

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Medtr8g027755.1 A0A072TMD1 PAC:31070261 Medicago truncatula 722  
AL3G51650.t1 PAC:35942001 Arabidopsis lyrata 196  
Bol012050 PAC:37351739 Brassica oleracea capitata 59  
Roisl.0091s0333.1.p PAC:39217201 Rorippa islandica 122  
Roisl.0210s1344.1.p PAC:39193821 Rorippa islandica 357  
Thlar.0030s0165.1.p PAC:39518111 Thlaspi arvense 128  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8425553
            2253872
            2163347
            12559563
            14693367