Protein Domain : IPR001867

Type:  Domain Name:  Signal transduction response regulator, C-terminal
Description:  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents a domain that is almost always found associated with the response regulator receiver domain (see ). It may play a role in DNA binding []. Short Name:  Sig_transdc_resp-reg_C
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00486
SM00862

5 Found Ins

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR016032 Domain Signal transduction response regulator, C-terminal effector
IPR006291 Family Transcriptional regulatory protein PcoR, heavy metal response
IPR011879 Family Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB
IPR022305 Family Sortase system response regulator

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR001867
GO:0000160 IPR001867
GO:0006355 IPR001867

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001867
GO:0000160 IPR001867
GO:0006355 IPR001867

0 Parent Features

229 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30763.m000019 B9THF8 PAC:16824604 Ricinus communis 228  
32547.m000025 B9TDT4 PAC:16825476 Ricinus communis 233  
33801.m000015 B9TFI0 PAC:16825994 Ricinus communis 230  
34537.m000024 B9TD62 PAC:16826257 Ricinus communis 181  
58918.m000019 B9TNB9 PAC:16829201 Ricinus communis 185  
27983.m000079 B9T8V8 PAC:16799682 Ricinus communis 139  
29022.m000039 B9T9H2 PAC:16802180 Ricinus communis 104  
28231.m000034 B9TBN5 PAC:16800422 Ricinus communis 231  
27472.m000314 B9T7I6 PAC:16798464 Ricinus communis 426  
Medtr1874s0010.1 A0A072TDR6 PAC:31106219 Medicago truncatula 239  
Pahal.J00353.1 PAC:32517463 Panicum hallii 227  
Pp3s32_693V3.1.p PAC:32948381 Physcomitrium patens 717  
Pp3s30_340V3.1.p PAC:32948538 Physcomitrium patens 697  
Pp3s30_381V3.1.p PAC:32948475 Physcomitrium patens 1103  
Pp3s30_380V3.1.p PAC:32948459 Physcomitrium patens 1103  
Pp3s32_10V3.1.p PAC:32948375 Physcomitrium patens 1383  
Pp3s32_240V3.1.p PAC:32948380 Physcomitrium patens 740  
Brdisv1pangenome1001094m.p PAC:33598971 Brachypodium distachyon Pangenome 238  
Brdisv1pangenome1001127m.p PAC:33621114 Brachypodium distachyon Pangenome 238  
Brdisv1pangenome1001128m.p PAC:33621115 Brachypodium distachyon Pangenome 229  
Brdisv1pangenome1004655m.p PAC:33655481 Brachypodium distachyon Pangenome 220  
Brdisv1pangenome1006312m.p PAC:33619695 Brachypodium distachyon Pangenome 229  
Brdisv1pangenome1006575m.p PAC:33623763 Brachypodium distachyon Pangenome 239  
Brdisv1pangenome1006714m.p PAC:33656860 Brachypodium distachyon Pangenome 236  
Brdisv1pangenome1006622m.p PAC:33659066 Brachypodium distachyon Pangenome 216  
Brdisv1pangenome1006660m.p PAC:33621914 Brachypodium distachyon Pangenome 229  
Brdisv1pangenome1006633m.p PAC:33621156 Brachypodium distachyon Pangenome 246  
Brdisv1pangenome1006136m.p PAC:33656440 Brachypodium distachyon Pangenome 224  
Brdisv1pangenome1006186m.p PAC:33659180 Brachypodium distachyon Pangenome 238  
Brdisv1pangenome1007298m.p PAC:33608251 Brachypodium distachyon Pangenome 226  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372152
            10966457
            16176121
            18076326
            11934609
            11489844
            9016718