Protein Domain : IPR001574

Type:  Family Name:  Ribosome-inactivating protein
Description:  A number of bacterial and plant toxins act by inhibiting protein synthesis in eukaryotic cells. The toxins of the shiga and ricin family inactivate 60S ribosomal subunits by an N-glycosidic cleavage which releases a specific adenine base from the sugar-phosphate backbone of 28S rRNA [, , ]. Members of the family include shiga and shiga-like toxins, and type I (e.g. trichosanthin and luffin) and type II (e.g. ricin, agglutinin and abrin) ribosome inactivating proteins (RIPs). All these toxins are structurally related. RIPs have been of considerable interest because of their potential use, conjugated with monoclonal antibodies, as immunotoxins to treat cancers. Further, trichosanthin has been shown to have potent activity against HIV-1-infected T cells and macrophages []. Elucidation of the structure-function relationships of RIPs has therefore become a major research effort. It is now known that RIPs are structurally related. A conserved glutamic residue has been implicated in the catalytic mechanism []; this lies near a conserved arginine, which also plays a role in catalysis []. Short Name:  Ribosome_inactivat_prot

1 Child Features

DB identifier Type Name
IPR017989 Family Ribosome-inactivating protein subgroup

3 Contains

DB identifier Type Name
IPR016139 Domain Ribosome-inactivating protein, subdomain 2
IPR016138 Domain Ribosome-inactivating protein, subdomain 1
IPR017988 Conserved_site Ribosome-inactivating protein conserved site

2 Cross Referencess

Identifier
PF00161
SSF56371

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0030598 IPR001574
GO:0017148 IPR001574

2 Ontology Annotations

GO Term Gene Name
GO:0030598 IPR001574
GO:0017148 IPR001574

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29791.m000533 B9SSU3 PAC:16808604 Ricinus communis 571  
29852.m001982 B9RKZ9 PAC:16811544 Ricinus communis 301  
29942.m000748 B9S6M3 PAC:16814307 Ricinus communis 300  
29942.m000749 B9S6M4 PAC:16814308 Ricinus communis 430  
29988.m000125 B9T5T9 PAC:16815180 Ricinus communis 574  
29988.m000128 B9T5U2 PAC:16815183 Ricinus communis 202  
30113.m001449 B9RRJ1 PAC:16817922 Ricinus communis 306  
36244.m000005 B9TG95 PAC:16826900 Ricinus communis 225  
60628.m00003 B9TD97 PAC:16829373 Ricinus communis 420  
60629.m00002 B9T8T0 PAC:16829374 Ricinus communis 576  
60637.m00004 B9T7K1 PAC:16829375 Ricinus communis 575  
60637.m00006 B9T7K2 PAC:16829376 Ricinus communis 583  
60638.m00018 B9T1S4 PAC:16829379 Ricinus communis 575  
60638.m00019 B9T1S2 PAC:16829380 Ricinus communis 437  
60638.m00022 B9T1S1 PAC:16829381 Ricinus communis 303  
60638.m00023 B9T1S0 PAC:16829382 Ricinus communis 574  
60638.m00025 B9T1R9 PAC:16829383 Ricinus communis 346  
29638.m000512 B9STV4 PAC:16804430 Ricinus communis 271  
29638.m000513 B9STV5 PAC:16804431 Ricinus communis 270  
28842.m000952 B9SBQ1 PAC:16801840 Ricinus communis 281  
Cucsa.001340.1 A0A0A0KN71 PAC:16950883 Cucumis sativus 534  
orange1.1g035420m A0A067D5C9 PAC:18134344 Citrus sinensis 62  
orange1.1g041832m A0A067DL82 PAC:18122427 Citrus sinensis 200  
Ciclev10033185m V4TB90 PAC:20804786 Citrus clementina 91  
Ciclev10033824m V4VDQ8 PAC:20802565 Citrus clementina 87  
Ciclev10033570m V4TB99 PAC:20805660 Citrus clementina 84  
Potri.017G011000.1 A0A2K1X1P6 PAC:26984647 Populus trichocarpa 374  
Potri.017G012000.1 A0A2K1X1S0 PAC:26984789 Populus trichocarpa 374  
Potri.013G003900.1 B9I6M3 PAC:26995740 Populus trichocarpa 171  
Gorai.013G087700.2 A0A0D2VB52 PAC:26786723 Gossypium raimondii 525  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1742358
            2714255
            3276522
            8411176
            3357883
            8066085