Protein Domain : IPR003561

Type:  Family Name:  Mutator MutT
Description:  MutT is a small bacterial protein (~12-15kDa) involved in the GO system [].MutT is known as a mutator gene because mutations in the gene specifically increase the rate of AT:GC tranversions. MutT is a 7,8-dihydro-8-oxoguanine triphosphatase converting 8-oxoguanine triphosphatase to the monophosphate with high efficiency. It acts both on 8-oxoGTP as well as 8-oxodGTP. It also can convert, less efficiently, the GDP and dGDP forms to the monophosphates [, ]. Consequently it reduces the availablity of 8-oxoGTP and the rate of mutation.A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic, viral, and eukaryotic proteins [, , , ]. Recently, the genericname `NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family [].The solution structure of the MutT enzyme has been solved by NMR []. Thestructure is globular and compact, and contains a five-stranded mixed beta-sheet. The parallel portion of the sheet is sandwiched between twoalpha-helices, forming an alpha+beta fold. Short Name:  Mutator_MutT
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0 Child Features

4 Contains

DB identifier Type Name
IPR000086 Domain NUDIX hydrolase domain
IPR015797 Domain NUDIX hydrolase domain-like
IPR020476 Domain NUDIX hydrolase
IPR020084 Conserved_site NUDIX hydrolase, conserved site

2 Cross Referencess

Identifier
PR01401
TIGR00586

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008413 IPR003561
GO:0006281 IPR003561

2 Ontology Annotations

GO Term Gene Name
GO:0008413 IPR003561
GO:0006281 IPR003561

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1011423m.p PAC:33658475 Brachypodium distachyon Pangenome 911  
Brdisv1BdTR11A1041208m.p PAC:35687832 Brachypodium distachyon BdTR11a 911  
Bobra.0162s0018.2.p PAC:40713590 Botryococcus braunii 236  
Bobra.0162s0018.1.p PAC:40713588 Botryococcus braunii 292  
Bobra.0162s0018.3.p PAC:40713589 Botryococcus braunii 292  
28964.m000068 B9T9L7 PAC:16802060 Ricinus communis 185  
28964.m000068 B9T9L7 PAC:16802060 Ricinus communis 185  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8810257
            1328155
            8226881
            8170394
            8233837
            7578113
            10373642
            9311918
            15850400