Protein Domain : IPR020084

Type:  Conserved_site Name:  NUDIX hydrolase, conserved site
Description:  MutT is a small bacterial protein (~12-15Kd) involved in the GO system [] responsible for removing an oxidatively damaged form of guanine (8-hydroxy-guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A.T to G.C transversions. MutTspecifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic, viral and eukaryotic proteins [, , , ].The generic name `NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family []. Thefamily can be divided into a number of subgroups, of which MutT anti- mutagenic activity represents only one type; most of the rest hydrolysediverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP).This signature covers the core region of the NUDIX domain and contains four conserved glutamate residues []. The region spanned by this signature could be part of the active centre of a family of pyrophosphate-releasing NTPases. Short Name:  NUDIX_hydrolase_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00893

12 Found Ins

DB identifier Type Name
IPR000086 Domain NUDIX hydrolase domain
IPR015797 Domain NUDIX hydrolase domain-like
IPR020476 Domain NUDIX hydrolase
IPR003563 Family 7,8-dihydro-8-oxoguanine triphosphatase
IPR003293 Family Nudix hydrolase 6-like
IPR003561 Family Mutator MutT
IPR004385 Family Nucleoside diphosphate pyrophosphatase
IPR014078 Family Nucleoside triphosphatase YtkD
IPR003562 Family Mutator MutX protein
IPR003564 Family Dihydroneopterin triphosphate diphosphatase
IPR003565 Family Bis(5'-nucleosyl)-tetraphosphatase
IPR003301 Family Vaccinia virus D10, decapping enzyme

1 GO Annotation

GO Term Gene Name
GO:0016787 IPR020084

1 Ontology Annotations

GO Term Gene Name
GO:0016787 IPR020084

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8810257
            1328155
            8226881
            8170394
            8233837
            10373642