| Type: | Family | Name: | 7,8-dihydro-8-oxoguanine triphosphatase |
| Description: | The enzyme 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase) is present in a variety of organisms, where it plays an important role in the control of spontaneous mutagenesis []. The enzyme degrades 8-oxoguanine-containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synthesis, to the corresponding monophosphate, therebypreventing misincorporation of 8-oxo-dGTP into DNA []. 8-oxo-dGTPase is an 18kDa protein containing 156 amino acid residues. The amino acid sequence shares a degree of similarity with the MutT domain of the Escherichia coliMutT protein, which has a distinct 8-oxo-dGTPase activity []. When human cDNA is expressed in E. coli mutT- mutant cells,there is a significant amount of 8-oxo-dGTPase activity and a reduced frequency of spontaneous mutation. Human 8-oxo-dGTPase is thought to protect genetic information from the untoward effects of endogenous oxygen radicals []. | Short Name: | OxG-triPHTase |
