Protein Domain : IPR008992

Type:  Domain Name:  Enterotoxin
Description:  Cholera toxin produced by Vibrio choleraeand heat-labile enterotoxin, produced by enterotoxigenic Escherichia coli, are AB5 heterohexamers, consisting of one A polypeptide and five identical B polypeptides, with an ADP-ribosylating A subunit and a GM1 receptor binding B pentamer. These toxins are among the most potent mucosal adjuvants known. The B pentamer is required for binding to the cell surface receptor ganglioside GM1. The A subunit can be proteolytically cleaved within the single disulphide-linked loop between two cysteine residues to produce the enzymatically active A1 polypeptide and the smaller A2 polypeptide that links fragment A1 to the B pentamer. Upon entry into enterocytes by endocytosis and following reduction and translocation, CT-A1 ADP-ribosylates a regulatory G-protein (Gsalpha), which leads to constitutive activation of adenylate cyclase, increased intracellular concentration of cyclic AMP, and secretion of fluid and electrolytes into the lumen of the small intestine []. All family members contain a common OB-fold, a five-stranded beta-sheet coiled to form a closed beta-barrel capped by an alpha-helix located between the third and fourth strands. Short Name:  Enterotoxin
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3 Child Features

DB identifier Type Name
IPR020063 Domain Bordetella pertussis toxin B, subunit 2/3, C-terminal
IPR015282 Domain Staphylococcal superantigen-like OB-fold domain
IPR006173 Domain Staphylococcal/Streptococcal toxin, OB-fold

1 Contains

DB identifier Type Name
IPR006126 Conserved_site Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site

1 Cross References

Identifier
SSF50203

8 Found Ins

DB identifier Type Name
IPR003189 Family Shiga-like toxin, beta subunit
IPR010503 Family Type II heat-labile enterotoxin, B subunit
IPR006177 Family Staphylococcal/streptococcal toxin, bacterial
IPR003899 Family Bordetella pertussis toxin B
IPR008375 Family Staphylococcus aureus exotoxin
IPR015355 Family Pertussis toxin, subunit S4
IPR015356 Family Pertussis toxin, subunit S5
IPR001835 Family Heat-labile enterotoxin, B chain

1 GO Annotation

GO Term Gene Name
GO:0009405 IPR008992

1 Ontology Annotations

GO Term Gene Name
GO:0009405 IPR008992

0 Parent Features

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30209.m001523 B9RXA7 PAC:16824067 Ricinus communis 204  
Glyma.16G198000.1.p A0A0R0G1J8 PAC:30561843 Glycine max 104  
Traes_2BL_2FB2AD407.1 PAC:31892910 Triticum aestivum 66  
Glyma.16G198000.1.p A0A0R0G1J8 PAC:41080698 Glycine max 104  
GlymaLee.16G160100.1.p A0A0R0G1J8 PAC:41301384 Glycine max Lee 104  
Solyc05g032670.2.1 PAC:41474988 Solanum lycopersicum 79  
SpFC.T115300.1.p PAC:41745229 Salix purpurea Fish Creek 71  
arahy.Tifrunner.gnm1.ann1.NJ4UUV.2 PAC:42603289 Arachis hypogaea 97  
Spov3_chr3.03788 PAC:45118391 Spinacia oleracea 87  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11395467