Protein Domain : IPR012902

Type:  PTM Name:  Prokaryotic N-terminal methylation site
Description:  This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N terminus of pilins and other proteins involved in secretion (see , , and ). There is a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue produced after cleavage, usually Phe, is methylated. Separate domains of the prepilin peptidase appear to be responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this region. Short Name:  N_methyl_site
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF07963
PF13544
PF13633
PS00409
TIGR02532

7 Found Ins

DB identifier Type Name
IPR016419 Family Prepilin peptidase-dependent protein B, predicted
IPR016785 Family ComG operon protein 4
IPR016940 Family ComG operon protein C
IPR016824 Family Tfp pilus assembly protein FimT
IPR002416 Family Type II secretion system protein H
IPR013362 Family Pilus modification type IV, PilV
IPR019836 Family Verru/Chthon cassette protein D

0 GO Annotation

0 Ontology Annotations

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
31398.m000032 B9TDC7 PAC:16825002 Ricinus communis 116  
31398.m000033 B9TDC8 PAC:16825003 Ricinus communis 316  
32511.m000032 B9TEX1 PAC:16825458 Ricinus communis 232  
34637.m000033 B9TFC7 PAC:16826296 Ricinus communis 109  
35909.m000032 B9TH70 PAC:16826782 Ricinus communis 227  
41056.m000021 B9TMI1 PAC:16827370 Ricinus communis 134  
45290.m000013 B9TNF7 PAC:16827787 Ricinus communis 304  

0 Publications