Protein Domain : IPR002416

Type:  Family Name:  Type II secretion system protein H
Description:  The general (type II) secretion pathway (GSP) within Gram-negative bacteria is a signal sequence-dependent process repsonsible for protein export [, , ]. The process has two stages: exoproteins are first translocated across the inner membrane by the general signal-dependent export pathway (GEP), and then across the outer membrane by a species-specific accessory mechanism. A number of proteins are involved in the GSP; one of these is known as protein H (GSPH protein). This protein shares several sequence similarities with bacterial fimbrial protein, or pilin, the major structural protein of pili []. Pili are polar flexible filamentous adhesions ~2500nm in length, and diameter ~5.4nm. Fimbrial and GSPG proteins share the following characteristics: a methylated, hydrophobic N-terminal residue; a hydrophobic leader peptide of 5-10 residues, terminating with glycine; glutamate as the fifth residue of the mature sequence; and a highly hydrophobic N terminus. Short Name:  T2SS_protein-H

0 Child Features

2 Contains

DB identifier Type Name
IPR022346 Domain General secretion pathway, GspH
IPR012902 PTM Prokaryotic N-terminal methylation site

2 Cross Referencess

Identifier
PR00885
TIGR01708

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008565 IPR002416
GO:0015628 IPR002416
GO:0015627 IPR002416

3 Ontology Annotations

GO Term Gene Name
GO:0008565 IPR002416
GO:0015628 IPR002416
GO:0015627 IPR002416

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8438237
            1592799
            1365398
            2677007