Protein Domain : IPR011895

Type:  Family Name:  Pyruvate-flavodoxin oxidoreductase
Description:  The oxidative decarboxylation of pyruvate to acetyl-CoA, a central step in energy metabolism, can occur by two different mechanisms []. In mitochondria and aerobic bacteria this reaction is catalysed by the multienzyme complex pyruvate dehydrogenase using NAD as electron acceptor. In anaerobic organisms, however, this reaction is reversibly catalysed by a single enzyme using either ferrodoxin or flavodoxin as the electron acceptor.Pyruvate:ferrodoxin/flavodoxin reductases (PFORs) in this entry occur in both obligately and facultatively anaerobic bacteria and also some eukaryotic microorganisms. These proteins are single-chain enzymes containing a thiamin pyrophosphate cofactor for the cleavage of carbon-carbon bonds next to a carbonyl group, and iron-sulphur clusters for electron transfer. The Desulfovibrio africanusenzyme is currently the only PFOR whose three dimensional structure is known [, ]. It is a homodimer where each subunit contains one thiamin pyrophosphate cofactor and two ferrodoxin-like 4Fe-S clusters and an atypical 4Fe-S cluster. Each monomer is composed of seven domains - domains I, II and VI make intersubunit contacts, while domains III, IV and V are located at the surface of the dimer, and domain VII forms a long arm extending over the other subunit. The cofactor is bound at the interface of domains I and VI and is proximal to the atypical 4Fe-S bound by domain VI, while the ferrodoxin-like 4Fe-S clusters are bound by domain V. Comparison of this enzyme with the multi-chain PFORs shows a correspondence between the domains in this enzyme and the subunits of the multi-chain enzymes. Short Name:  Pyrv_flavodox_OxRed
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0 Child Features

5 Contains

DB identifier Type Name
IPR011766 Domain Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR019752 Domain Pyruvate/ketoisovalerate oxidoreductase, catalytic domain
IPR002869 Domain Pyruvate-flavodoxin oxidoreductase, central domain
IPR019456 Domain Pyruvate-flavodoxin oxidoreductase, EKR domain
IPR002880 Domain Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal

2 Cross Referencess

Identifier
PIRSF000159
TIGR02176

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005506 IPR011895
GO:0016903 IPR011895
GO:0022900 IPR011895
GO:0055114 IPR011895

4 Ontology Annotations

GO Term Gene Name
GO:0005506 IPR011895
GO:0016903 IPR011895
GO:0022900 IPR011895
GO:0055114 IPR011895

0 Parent Features

8 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre02.g095137.t1.1 A0A2K3E1V3 PAC:30785750 Chlamydomonas reinhardtii 1345  
Cre02.g095137.t2.1 A0A2K3E1U7 PAC:30785751 Chlamydomonas reinhardtii 1327  
Brdisv1pangenome1013250m.p PAC:33659248 Brachypodium distachyon Pangenome 1441  
Brdisv1BdTR12c1040021m.p PAC:34402576 Brachypodium distachyon BdTR12c 1542  
Brdisv1BdTR11A1040036m.p PAC:35696730 Brachypodium distachyon BdTR11a 1217  
Vocar.0001s1094.1.p PAC:32884516 Volvox carteri 1205  
Vocar.0001s1094.2.p PAC:32884517 Volvox carteri 1165  
Vocar.0028s0137.1.p PAC:32895715 Volvox carteri 1298  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10048931
            11752578
            10607667