Protein Domain : IPR018145

Type:  Domain Name:  CagE, TrbE, VirB component of type IV transporter system, central domain
Description:  This domain is found in (amongst others): the Helicobacter pyloriprotein CagE (see examples), which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pyloriinduced gastritis and peptic ulceration []. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastricepithelial cell apoptosis in vitro[]. Similar type IV transport systems are also found in other bacteria. This domain is also found in proteins from the trb and Vir conjugal transfer systems in Agrobacterium tumefaciensand homologues of VirB proteins from other species. Short Name:  CagE_TrbE_VirB_cntrl_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03135

1 Found In

DB identifier Type Name
IPR004346 Family CagE, TrbE, VirB component of type IV transporter system

1 GO Annotation

GO Term Gene Name
GO:0005524 IPR018145

1 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR018145

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Medtr0448s0020.1 A0A072TFD3 PAC:31061954 Medicago truncatula 3238  
Medtr0787s0010.1 A0A072TDU3 PAC:31106213 Medicago truncatula 1728  
Zm00008a017655_P01 PAC:37196229 Zea mays PH207 125  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11104802
            11447179