Protein Domain : IPR004346

Type:  Family Name:  CagE, TrbE, VirB component of type IV transporter system
Description:  This family includes the Helicobacter pyloriprotein CagE (see examples), which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known,but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pyloriinduced gastritis and peptic ulceration []. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastricepithelial cell apoptosis in vitro[]. Similar type IV transport systems are also found in other bacteria. This family includes proteins from the trb and Vir conjugal transfer systems in Agrobacterium tumefaciensand homologues of VirB proteins from other species. Short Name:  CagE_TrbE_VirB
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0 Child Features

1 Contains

DB identifier Type Name
IPR018145 Domain CagE, TrbE, VirB component of type IV transporter system, central domain

1 Cross References

Identifier
TIGR00929

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0005524 IPR004346

1 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR004346

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11104802
            11447179