Protein Domain : IPR001946

Type:  Family Name:  Alpha 2A adrenoceptor
Description:  The adrenoceptors (or adrenergic receptors) are rhodopsin-like G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system, effect blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The clinical uses of adrenergic compounds are vast. Agonists and antagonists interacting with adrenoceptors have proved useful in the treatment of a variety of diseases, including hypertension, angina pectoris, congestive heart failure, asthma, depression, benign prostatic hypertrophy, and glaucoma. These drugs are also useful in several other therapeutic situations including shock, premature labour and opioid withdrawal, and as adjuncts to general anaesthetics.There are three classes of adrenoceptors, based on their sequence similarity, receptor pharmacology and signalling mechanisms []. These three classes are alpha 1 (a Gq coupled receptor), alpha 2 (a Gi coupled receptor) and beta (a Gs coupled receptor), and each can be further divided into subtypes []. The different subtypes can coexist in some tissues, but one subtype normally predominates.There are three subtpyes of alpha 2 adrenoceptors (2A-C). The receptors are usually found presynaptically, where they inhibit the release of noradrenaline, and thus serve as an important receptor in the negative feedback control of noradrenaline release [, , , ]. Postsynaptic alpha 2 receptors are located on liver cells, platelets, and the smooth muscle of blood vessels. Activation of the receptors causes platelet aggregation [], blood vessel constriction [, ] and constriction of vascular smooth muscle []. Agonists of alpha 2 adrenergic receptors are frequently used in veterinary anaesthesia, where they affect sedation, muscle relaxation and analgesia through their effects on the CNS []. Alpha 2 adrenoceptors are coupled through the Gi/Go mechanism, inhibiting adenylate cyclase activity and downregulating cAMP formation. This entry represents the alpha 2A adrenoceptor. It is expressed at high levels in the CNS, and in peripheral tissues such as kidney, aorta, skeletal muscle, spleen and lung [, , , ]. Short Name:  ADRA2A_rcpt
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR24248:SF24
PR00558

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004938 IPR001946
GO:0006940 IPR001946
GO:0007186 IPR001946
GO:0019229 IPR001946
GO:0030168 IPR001946
GO:0016021 IPR001946

6 Ontology Annotations

GO Term Gene Name
GO:0004938 IPR001946
GO:0006940 IPR001946
GO:0007186 IPR001946
GO:0019229 IPR001946
GO:0030168 IPR001946
GO:0016021 IPR001946

1 Parent Features

DB identifier Type Name
IPR002233 Family Adrenoceptor family

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brame.10PG013800.1.p PAC:45251335 Brachypodium mexicanum 123  
Brame.10PG007100.1.p PAC:45250092 Brachypodium mexicanum 195  

15 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18882199
            2855960
            2887122
            9280371
            9605427
            9760042
            9824686
            8670422
            15684247
            2574568
            10215710
            7812219
            7684725
            7688069
            1334200