Protein Domain : IPR002233

Type:  Family Name:  Adrenoceptor family
Description:  The adrenoceptors (or adrenergic receptors) are rhodopsin-like G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system, effect blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The clinical uses of adrenergic compounds are vast. Agonists and antagonists interacting with adrenoceptors have proved useful in the treatment of a variety of diseases, including hypertension, angina pectoris, congestive heart failure, asthma, depression, benign prostatic hypertrophy, and glaucoma. These drugs are also useful in several other therapeutic situations including shock, premature labour and opioid withdrawal, and as adjuncts to general anaesthetics.There are three classes of adrenoceptors, based on their sequence similarity, receptor pharmacology and signalling mechanisms []. These three classes are alpha 1 (a Gq coupled receptor), alpha 2 (a Gi coupled receptor) and beta (a Gs coupled receptor), and each can be further divided into subtypes []. The different subtypes can coexist in some tissues, but one subtype normally predominates.This entry represents the adrenoceptor family. Short Name:  ADR_fam
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9 Child Features

DB identifier Type Name
IPR001946 Family Alpha 2A adrenoceptor
IPR000507 Family Beta 1 adrenoceptor
IPR001115 Family Alpha 1B adrenoceptor
IPR000735 Family Alpha 2C adrenoceptor
IPR000681 Family Beta 3 adrenoceptor
IPR001004 Family Alpha 1A adrenoceptor
IPR000363 Family Alpha 1D adrenoceptor
IPR000207 Family Alpha 2B adrenoceptor
IPR000332 Family Beta 2 adrenoceptor

0 Contains

1 Cross References

Identifier
PR01103

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004935 IPR002233
GO:0007186 IPR002233
GO:0016021 IPR002233

3 Ontology Annotations

GO Term Gene Name
GO:0004935 IPR002233
GO:0007186 IPR002233
GO:0016021 IPR002233

1 Parent Features

DB identifier Type Name
IPR000276 Family G protein-coupled receptor, rhodopsin-like

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18882199
            2855960