Protein Domain : IPR000276

Type:  Family Name:  G protein-coupled receptor, rhodopsin-like
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].This entry represents the G protein-coupled receptor, rhodopsin-like family. Short Name:  GPCR_Rhodpsn
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75 Child Features

DB identifier Type Name
IPR003980 Family Histamine H3 receptor
IPR004065 Family Lysophosphatidic acid receptor
IPR004061 Family Sphingosine 1-phosphate receptor
IPR000204 Family Orexin receptor family
IPR000355 Family Chemokine receptor family
IPR004071 Family Cysteinyl leukotriene receptor
IPR008361 Family Melanin-concentrating hormone receptor
IPR028016 Family Hydroxycarboxylic acid receptor 1
IPR028017 Family Hydroxycarboxylic acid receptor 2/3
IPR028334 Family G protein-coupled receptor 55 orphan
IPR028335 Family G protein-coupled receptor 18 orphan
IPR028336 Family Glucose-dependent insulinotropic receptor
IPR002231 Family 5-hydroxytryptamine receptor family
IPR002120 Family Thyrotropin-releasing hormone receptor
IPR002131 Family Glycoprotein hormone receptor family
IPR000929 Family Dopamine receptor family
IPR008112 Family Relaxin receptor
IPR000499 Family Endothelin receptor family
IPR002002 Family Octopamine receptor
IPR001817 Family Vasopressin receptor
IPR000586 Family Somatostatin receptor family
IPR000995 Family Muscarinic acetylcholine receptor family
IPR000826 Family Formyl peptide receptor-related
IPR002230 Family Cannabinoid receptor family
IPR002233 Family Adrenoceptor family
IPR002232 Family 5-Hydroxytryptamine 6 receptor
IPR001760 Family Opsin
IPR026234 Family Mas-related G protein-coupled receptor family
IPR000025 Family Melatonin receptor family
IPR002275 Family G protein-coupled receptor 1 orphan

0 Contains

3 Cross Referencess

Identifier
PF00001
PR00237
PS00237

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004930 IPR000276
GO:0007186 IPR000276
GO:0016021 IPR000276

3 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR000276
GO:0007186 IPR000276
GO:0016021 IPR000276

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Potri.008G206000.1 PAC:27036086 Populus trichocarpa 341  
Oropetium_20150105_17223A PAC:36017058 Oropetium thomaeum 307  
HanXRQChr08g0233781 A0A251U8P9 PAC:40345610 Helianthus annuus 687  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2111655
            2830256
            8386361
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278