3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004952 | IPR000929 |
| GO:0007186 | IPR000929 |
| GO:0005887 | IPR000929 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
| Type: | Family | Name: | Dopamine receptor family |
| Description: | Dopamine receptors are members of the rhodopsin-like G-protein coupled receptor family and are prominent in the vertebrate central nervous system (CNS). Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders [], including social phobia [], Tourette's syndrome [], Parkinson's disease [], schizophrenia [], neuroleptic malignant syndrome [], attention-deficit hyperactivity disorder (ADHD) [] and drug and alcohol dependence [, ]. As a result, dopamine receptors are common drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors [, , , ].There are at least five different known subtypes of dopamine receptors designated D1, D2, D3, D4 and D5 []. They are distinguished by their G-protein coupling, ligand specificity, anatomical distribution and physiological effects. Dopamine receptors are divided into two further subfamilies. The D1-like family consists of D1 and D5 receptors, which couple to Gs and mediate excitatory neurotransmission. The D2-like family, meanwhile, consists of D2, D3 and D4 receptors, which couple to Gi/Go and mediate inhibitory neurotransmission. Although dopamine receptors are widely distributed in the brain, they are found in different locations that have different receptor type densities, presumably reflecting different functional roles []. D1 and D2 receptor subtypes are found at 10-100 times the levels of the D3, D4, D5 subtypes [].This entry represents the dopamine receptor family. | Short Name: | Dopamine_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0004952 | IPR000929 |
| GO:0007186 | IPR000929 |
| GO:0005887 | IPR000929 |
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
