Protein Domain : IPR002231

Type:  Family Name:  5-hydroxytryptamine receptor family
Description:  5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics []. The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [], and they activate an intracellular second messenger cascade to produce their responses. This entry represents the 5-hydroxytryptamine receptor family. Short Name:  5HT_rcpt
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10 Child Features

DB identifier Type Name
IPR002147 Family 5-Hydroxytryptamine 1B receptor
IPR001397 Family 5-Hydroxytryptamine 5A receptor
IPR000482 Family 5-Hydroxytryptamine 2B receptor
IPR000377 Family 5-Hydroxytryptamine 2C receptor
IPR000450 Family 5-Hydroxytryptamine 1F receptor
IPR000455 Family 5-Hydroxytryptamine 2A receptor
IPR000610 Family 5-Hydroxytryptamine 1A receptor
IPR000505 Family 5-Hydroxytryptamine 1D receptor
IPR000431 Family 5-Hydroxytryptamine 5B receptor
IPR027425 Family 5-Hydroxytryptamine 1E receptor

0 Contains

1 Cross References

Identifier
PR01101

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004993 IPR002231
GO:0007186 IPR002231
GO:0005887 IPR002231

3 Ontology Annotations

GO Term Gene Name
GO:0004993 IPR002231
GO:0007186 IPR002231
GO:0005887 IPR002231

1 Parent Features

DB identifier Type Name
IPR000276 Family G protein-coupled receptor, rhodopsin-like

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18476671
            11989819