| Type: | Family | Name: | 5-Hydroxytryptamine 1D receptor |
| Description: | 5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics []. The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [], and they activate an intracellular second messenger cascade to produce their responses. The 5-HT1 receptors are a subfamily of 5-HT receptors that were originally classified according to their inhibition of adenylyl cyclase, degree of sequence similarity and their overlapping pharmacological specificities. The subfamily is comprised of five different receptors 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, and they can couple to Gi/Go and mediate inhibitory neurotransmission, although signalling via other transduction systems are known. One of the 5-HT1 receptors, the 5-HT1E receptor, is yet to achieve receptor status from the International Union of Basic and Clinical Pharmacology (IUPHAR), since a robust response mediated via the protein has not been reported in the literature.This entry represents 5-HT1D receptor. It shares almost identical pharmacology with 5-HT1B receptor, but they differ in their level of expression: the level of 5-HT1D expression is very low compared with that of 5-HT1B receptors [, ]. 5-HT1D receptors are found in neurons in the CNS and in vascular smooth muscles in the periphery, and affect locomotion and anxiety [, , , , , ]. In the brain they are involved in vascular vasoconstriction and, as a result, 5-HT1D receptors are the therapeutic targets of the anti-migraine 'triptans' (e.g. sumitriptan and zolmitriptan), which are used to treat acute migraine attack []. 5-HT1D receptors are also implicated in feeding behaviour, anxiety, depression. It has also been suggested that 5-HT1D receptors have a stimulatory effect on growth hormone secretion, possibly by inhibiting hypothalamic somatostatin release [, ]. | Short Name: | 5HT1D_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR000505 |
| GO:0006939 | IPR000505 |
| GO:0007186 | IPR000505 |
| GO:0007268 | IPR000505 |
| GO:0040012 | IPR000505 |
| GO:0042310 | IPR000505 |
| GO:0050795 | IPR000505 |
| GO:0005887 | IPR000505 |
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR000505 |
| GO:0006939 | IPR000505 |
| GO:0007186 | IPR000505 |
| GO:0007268 | IPR000505 |
| GO:0040012 | IPR000505 |
| GO:0042310 | IPR000505 |
| GO:0050795 | IPR000505 |
| GO:0005887 | IPR000505 |
