3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR000431 |
| GO:0007186 | IPR000431 |
| GO:0016021 | IPR000431 |
| Type: | Family | Name: | 5-Hydroxytryptamine 5B receptor |
| Description: | 5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics []. The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [], and they activate an intracellular second messenger cascade to produce their responses. This entry represents the 5-HT5B receptor. As yet it has only been experimentally characterised in rodents, but not in humans []. The 5HT5B protein has a structure consistent with GPCRs, however, the human 5-HT5B gene does not encode a functional protein, because its coding sequence is interrupted by stop codons []. It is believed that the function of the 5HT5B receptor has been replaced in humans by some other subclass of 5-HT receptor []. In the CNS, it is found in the habenula, hippocampus and inferior olivary of rat brains [, , ]. Known agonists for 5-HT5B include ergotamine and LSD, and known antagonists include methiothepin. 5-HT5B receptors may play a role in sleep [] and serve as an presynaptic serotonin autoreceptor []. | Short Name: | 5HT5B_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR000431 |
| GO:0007186 | IPR000431 |
| GO:0016021 | IPR000431 |
