Protein Domain : IPR002230

Type:  Family Name:  Cannabinoid receptor family
Description:  Cannabinoid receptors are a class of cell membrane receptors that belong to the rhodopsin-like G-protein coupled receptor (GPCR) family [, , ]. Typical of G protein-coupled receptors, cannabinoid receptors contain seven transmembrane spanning domains []. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, such as N-arachidonoylethanolamine and 2-arachidonoyl glycerol (produced by the mammalian body), plant cannabinoids, such as tetrahydrocannabinol [, ] (produced by the plant Cannabis sativa ) and synthetic cannabinoids, such as HU-210 []. Currently, two known cannabinoid receptor subtypes have been identified, CB1 receptor and CB2 receptor [, ], and are phylogenetically restricted to the chordate branch of the animal kingdom []. The International Union of Basic and Clinical Pharmacology (IUPHAR) has identified five pharmacological targets that could be used to find new cannabinoid receptors or channels [], which has resulted in a number of cannabinoid receptors being considered. TRP vanilloid 1 (), which is thought to function as an ionotropic cannabinoid receptor [], and some deorphanised GPCRs []: GPR18, GPR55, GPR119. However, according to the criteria, no channel, non-CB1/CB2 established receptor or deorphanised receptor can currently be classified fully as a novel cannabinoid receptor [].This entry represents the cannabinoid receptor family, which includes cannabinoid receptor 1 and cannabinoid receptor 2. Short Name:  Cnbnoid_rcpt
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2 Child Features

DB identifier Type Name
IPR001551 Family Cannabinoid receptor type 2
IPR000810 Family Cannabinoid receptor type 1

0 Contains

1 Cross References

Identifier
PR00362

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004949 IPR002230
GO:0007186 IPR002230
GO:0016021 IPR002230

3 Ontology Annotations

GO Term Gene Name
GO:0004949 IPR002230
GO:0007186 IPR002230
GO:0016021 IPR002230

1 Parent Features

DB identifier Type Name
IPR000276 Family G protein-coupled receptor, rhodopsin-like

0 Proteins

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21079038
            12432948
            18426493
            19273110
            6268916
            5538858
            7565624
            2165569
            7689702