3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004949 | IPR001551 |
| GO:0007186 | IPR001551 |
| GO:0016021 | IPR001551 |
| Type: | Family | Name: | Cannabinoid receptor type 2 |
| Description: | Cannabinoid receptors are a class of cell membrane receptors that belong to the rhodopsin-like G-protein coupled receptor (GPCR) family [, , ]. Typical of G protein-coupled receptors, cannabinoid receptors contain seven transmembrane spanning domains []. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, such as N-arachidonoylethanolamine and 2-arachidonoyl glycerol (produced by the mammalian body), plant cannabinoids, such as tetrahydrocannabinol [, ] (produced by the plant Cannabis sativa ) and synthetic cannabinoids, such as HU-210 []. Currently, two known cannabinoid receptor subtypes have been identified, CB1 receptor and CB2 receptor [, ], and are phylogenetically restricted to the chordate branch of the animal kingdom []. The International Union of Basic and Clinical Pharmacology (IUPHAR) has identified five pharmacological targets that could be used to find new cannabinoid receptors or channels [], which has resulted in a number of cannabinoid receptors being considered. TRP vanilloid 1 (), which is thought to function as an ionotropic cannabinoid receptor [], and some deorphanised GPCRs []: GPR18, GPR55, GPR119. However, according to the criteria, no channel, non-CB1/CB2 established receptor or deorphanised receptor can currently be classified fully as a novel cannabinoid receptor [].This entry represents cannabinoid receptor 2 (CB2), which is found primarily in immune tissue [], specifically T cells of the immune system, on macrophages and B cells, and in hematopoietic cells [, ]. The CB2 receptor is closely related to CB1 receptor exhibiting 68% homology []. The CB2 receptor has been shown to bind cannabinoid and aminoalkylindole compounds and to signal a response through the inhibition of adenylate cyclase [, , , , ]. The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG) [, , ]. The primary effect of the CB2 receptor is mainly on the immunological activity of leukocytes [], and it has specifically been implicated in a variety of modulatory functions, including immune suppression, induction of apoptosis, and induction of cell migration [, ]. CB2 receptors may have possible therapeutic roles in the treatment of neurodegenerative disorders such as Alzheimer's disease [, ]. | Short Name: | Canbinoid_rcpt_2 |
| GO Term | Gene Name |
|---|---|
| GO:0004949 | IPR001551 |
| GO:0007186 | IPR001551 |
| GO:0016021 | IPR001551 |
