3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004994 | IPR000586 |
| GO:0007186 | IPR000586 |
| GO:0016021 | IPR000586 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
| Type: | Family | Name: | Somatostatin receptor family |
| Description: | Somatostatin (SST), also known as somatotropin release-inhibiting factor (SRIF), is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Somatostatin has a wide distribution throughout the central nervous system (CNS) as well as in peripheral tissues, for example in the pituitary, pancreas and stomach. The various actions of somatostatin are mediated by a family of rhodopsin-like G protein-coupled receptors, which comprise of five distinct subtypes: Somatostatin receptor 1 (SSTR1), Somatostatin receptor 2 (SSTR2), Somatostatin receptor 3 (SSTR3), Somatostatin receptor 4 (SSTR4) and Somatostatin receptor 5 (SSTR5) [, , ]. These subtypes are widely expressed in many tissues [, , , , , ], and frequently multiple subtypes coexist in the same cell []. The somatostatin receptor subtypes also share common signalling pathways, such as the inhibition of adenylyl cyclase [, ], activation of phosphotyrosine phosphatase (PTP), and modulation of mitogen-activated protein kinase (MAPK) through G protein-dependent mechanisms. Some of the subtypes are also coupled to inward rectifying K+ channels (SSTR2, SSTR3, SSTR4, SSTR5) [, ], to voltage-dependent Ca2+ channels (SSTR1, SSTR2) [], to an Na+/H+ exchanger (SSTR1), AMPA/kainate glutamate channels (SSTR1, SSTR2), phospholipase C (SSTR2, SSTR5), and phospholipase A2 (SSTR4) []. Amongst the wide spectrum of somatostatin effects, several biological responses have been identified that display absolute or relative subtype selectivity. These include GH secretion (SSTR2 and 5), insulin secretion (SSTR5), glucagon secretion (SSTR2), and immune responses (SSTR2) [].This entry represents the somatostatin family. | Short Name: | Somatstn_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0004994 | IPR000586 |
| GO:0007186 | IPR000586 |
| GO:0016021 | IPR000586 |
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
