3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR002232 |
| GO:0007186 | IPR002232 |
| GO:0016021 | IPR002232 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
| Type: | Family | Name: | 5-Hydroxytryptamine 6 receptor |
| Description: | 5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics []. The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [], and they activate an intracellular second messenger cascade to produce their responses. 5-HT6 receptors are positively coupled to adenylyl cyclase. They are expressed almost exclusively in the brain [] and prominently expressed in the caudate nucleus [, , ]. Based on their abundance in extrapyramidal, limbic and cortical regions of the brain, it has been suggested that the 5-HT6 receptors play a role in functions like motor control, emotionality, cognition and memory [, , ]. Blockade of central 5-HT6 receptors has been shown to increase glutamatergic and cholinergic neurotransmission in various brain areas [, , ], whereas activation enhances GABAergic signaling in a widespread manner []. Antagonism of 5-HT6 receptors also facilitates dopamine and norepinephrine release in the frontal cortex [, ], while stimulation has the opposite effect []. 5-HT6 receptors have high affinity for several typical and atypical antipsychotic agents, including clozapine, olanzapine fluperlapine and seroquel [, ]. This attribute has led to speculation of potential involvement of the 5-HT6 receptor in the pathogenesis of psychiatric disorders. 5-HT6 receptor antagonists have been demonstrated to be active in rodent models of depression, anxiety and obsessive-compulsive disorder, and such agents may be useful treatments for these conditions [, ]. There is also some evidence of enhanced retention of spatial learning following treatment with such compounds [, ]. However, it should be noted that the rodent brain has a notably different regional pattern of 5-HT6 receptor expression in comparison to humans, and little data has been generated in actual clinical populations. | Short Name: | 5HT6_rcpt |
| GO Term | Gene Name |
|---|---|
| GO:0004993 | IPR002232 |
| GO:0007186 | IPR002232 |
| GO:0016021 | IPR002232 |
| DB identifier | Type | Name |
|---|---|---|
| IPR000276 | Family | G protein-coupled receptor, rhodopsin-like |
