Protein Domain : IPR000355

Type:  Family Name:  Chemokine receptor family
Description:  Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).This entry represents the chemokine receptor family. Short Name:  Chemokine_rcpt
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19 Child Features

DB identifier Type Name
IPR004069 Family CC chemokine receptor 9
IPR004067 Family CC chemokine receptor 6
IPR004068 Family CC chemokine receptor 8
IPR004070 Family CXC chemokine receptor 3
IPR002235 Family CXC chemokine receptor 6
IPR002237 Family CC chemokine receptor 2
IPR002236 Family CC chemokine receptor 1
IPR002239 Family CC chemokine receptor 4
IPR002238 Family CC chemokine receptor 3
IPR002240 Family CC chemokine receptor 5
IPR000174 Family CXC chemokine receptor 1/2
IPR005382 Family CC chemokine receptor 10
IPR005383 Family CC chemokine receptor like 1
IPR005387 Family CX3C chemokine receptor 1
IPR005393 Family XC chemokine receptor 1
IPR001053 Family CXC chemokine receptor 5
IPR001277 Family CXC chemokine receptor 4
IPR001416 Family CXC chemokine receptor 7
IPR001718 Family CC chemokine receptor 7

1 Contains

DB identifier Type Name
IPR022726 Domain CXC chemokine receptor 4 N-terminal domain

2 Cross Referencess

Identifier
PTHR24227
PR00657

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004950 IPR000355
GO:0006935 IPR000355
GO:0007186 IPR000355
GO:0016021 IPR000355

4 Ontology Annotations

GO Term Gene Name
GO:0004950 IPR000355
GO:0006935 IPR000355
GO:0007186 IPR000355
GO:0016021 IPR000355

1 Parent Features

DB identifier Type Name
IPR000276 Family G protein-coupled receptor, rhodopsin-like

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11544102
            10714678
            10601351
            9500790
            9689100
            7592998