Protein Domain : IPR026234

Type:  Family Name:  Mas-related G protein-coupled receptor family
Description:  Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine [] and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents the mas-related G protein-coupled receptor family. Short Name:  MRGPCRFAMILY
Paste the following link

7 Child Features

DB identifier Type Name
IPR026230 Family Mas-related G protein-coupled receptor E
IPR026232 Family Mas-related G protein-coupled receptor D
IPR026233 Family Mas-related G protein-coupled receptor A
IPR027336 Family Mas-related G protein-coupled receptor G
IPR027341 Family Mas-related G protein-coupled receptor X2
IPR026221 Family Mas-related G protein-coupled receptor H
IPR026228 Family Mas-related G protein-coupled receptor F

0 Contains

2 Cross Referencess

Identifier
PTHR11334
PR02108

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004930 IPR026234
GO:0007186 IPR026234
GO:0016021 IPR026234

3 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR026234
GO:0007186 IPR026234
GO:0016021 IPR026234

1 Parent Features

DB identifier Type Name
IPR000276 Family G protein-coupled receptor, rhodopsin-like

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            20004959
            12397184
            12084918
            18250432
            21460831